In this book we present different topics from safety science and technology, including: safety-critical systems, safety simulation techniques, safety in transport and vehicles, and safety analysis in medicine (hospitals). Section 1 focuses on safety-critical systems, describing architecture level safety analyses for safety-critical systems, safety assessment of nuclear power plants for liquefaction consequences, the Fukushima nuclear accident: insights on the safety aspects, an augmented framework for formal analysis of safety critical systems, and concepts of safety critical systems unification approach & security assurance process. Section 2 focuses on safety simulation techniques, describing the marine safety simulation based electronic chart display and information system, improved modelling and assessment of the performance of firefighting means in the frame of a fire PSA, scenario grouping and classification methodology for postprocessing of data generated by integrated deterministic-probabilistic safety analysis, demonstration of emulator-based Bayesian calibration of safety analysis codes: theory and formulation, microscopic simulation-based high occupancy vehicle lane safety and operation assessment: a case study. Section 3 focuses on safety in transport and vehicles, describing safety of autonomous vehicles, studying the safety impact of autonomous vehicles using simulation-based surrogate safety measures, advanced modeling and simulation of vehicle active aerodynamic safety, and analyzing driving safety using vehicle-water-filled rutting dynamics model and simulation. Section 4 focuses on safety analysis in medicine (hospitals), describing establishing patient safety in intensive care - a grounded theory, analysis of critical incidents during anesthesia in a tertiary hospital, healthcare professional's perception of patient safety measured by the hospital survey on patient safety culture: a systematic review and meta-analysis, and uncertainty of clinical thinking and patient safety.