This book covers topics from numerical and symbolic computing, including the main numerical and symbolic methods, schemes and applications. Section 1 focuses on numerical computing methods, describing matrix differential equations for solving systems of linear algebraic equations, a numerical problem encryption for high-performance computing applications, a numerical verification method of solutions for elliptic variational inequalities, a trigonometric numerical integrator for solving first order ordinary differential equation, and augmented Lagrangian methods for numerical solutions to higher order differential equations. Section 2 focuses on symbolic computing methods, describing a learning network assisted by means of symbolic computation, multiple factorial analysis of symbolic data, combining symbolic tools with interval analysis, and application to solve robust control problems, symbolic and graphical computations of a class of slightly perturbed equations. Section 3 focuses on numerical computing applications, describing non-negativity preserving numerical algorithms for problems in mathematical finance, a continuum approach using numerical simulations of microscale gas flows, numerical methods in electro-cardiology, numerical simulation of the blood flow through a brain vascular aneurysm with an artificial stent using the SPH method, and numerical modeling of soil water flow and nitrogen dynamics in a tomato field irrigated with municipal wastewater. Section 4 focuses on symbolic computing applications, describing symbolic time series analysis and its application in social sciences, application of symbolic computation in nonlinear differential-difference equations, symbolic modelling of dynamic human motions, and a framework for bridging the gap between symbolic and non-symbolic AI.